| 1987 | Firehouse | Babs | |
| 1988 | Blood Red | Maria Collogero | |
| 1988 | Mystic Pizza | Daisy Arujo | Nominated—Independent Spirit Award for Best Lead Female
Nominated—Young Artist Award for Best Young Actress in a Motion Picture – Drama |
| 1988 | Satisfaction | Daryle | Also known as Girls of Summer |
| 1989 | Steel Magnolias | Shelby Eatenton Latcherie | Golden Globe Award for Best Supporting Actress – Motion Picture
Nominated—Academy Award for Best Supporting Actress |
| 1990 | Pretty Woman | Vivian Ward | Blimp Award for Favorite Movie Actress
Golden Globe Award for Best Actress – Motion Picture Musical or Comedy
Nominated—Academy Award for Best Actress
Nominated—BAFTA Award for Best Actress in a Leading Role |
| 1990 | Flatliners | Rachel Mannus | Nominated—Saturn Award for Best Supporting Actress |
| 1991 | Hook | Tinkerbell | Nominated—Razzie Award for Worst Supporting Actress |
| 1991 | Dying Young | Hilary O'Neil | Nominated—MTV Movie Award for Best Female Performance
Nominated—MTV Movie Award for Most Desirable Female |
| 1991 | Sleeping with the Enemy | Sara Waters/Laura Burney | Nominated—Saturn Award for Best Actress |
| 1992 | The Player | | Cameo |
| 1993 | The Pelican Brief | Darby Shaw | Nominated—MTV Movie Award for Best Female Performance |
| 1994 | Prêt-à-Porter | Anne Eisenhower | Also known as Ready to Wear
National Board of Review Award for Best Cast |
| 1994 | I Love Trouble | Sabrina Peterson | |
| 1995 | Something to Talk About | Grace King Bichon | |
| 1996 | Everyone Says I Love You | Von Sidell | |
| 1996 | Michael Collins | Kitty Kiernan | |
| 1996 | Mary Reilly | Mary Reilly | Nominated—Razzie Award for Worst Actress |
| 1997 | Conspiracy Theory | Alice Sutton | Blockbuster Entertainment Award for Favorite Actress – Suspense |
| 1997 | My Best Friend's Wedding | Julianne Potter | Blockbuster Entertainment Award for Favorite Actress – Comedy
Nominated—Golden Globe Award for Best Actress – Motion Picture Musical or Comedy
Nominated—Satellite Award for Best Actress – Motion Picture Musical or Comedy
Nominated—MTV Movie Award for Best Female Performance |
| 1998 | Stepmom | Isabel Kelly | Nominated—Blimp Award for Favorite Movie Actress
Blockbuster Entertainment Award for Favorite Actress – Drama |
| 1999 | Runaway Bride | Maggie Carpenter | Nominated—Blimp Award for Favorite Movie Actress (also for Notting Hill)
Nominated—Blockbuster Entertainment Award for Favorite Actress – Comedy/Romance
Nominated—Csapnivalo Award for Best Female Performance
Nominated—MTV Movie Award for Best Female Performance |
| 1999 | Notting Hill | Anna Scott | Nominated—Blimp Award for Favorite Movie Actress (also for Runaway Bride)
Nominated—Blimp Award for Favorite Movie Couple (shared with Hugh Grant)
Nominated—Blockbuster Entertainment Award for Favorite Actress – Comedy/Romance
Nominated—Golden Globe Award for Best Actress – Motion Picture Musical or Comedy
Nominated—Satellite Award for Best Actress - Motion Picture Musical or Comedy |
| 2000 | Erin Brockovich | Erin Brockovich | Academy Award for Best Actress
BAFTA Award for Best Actress in a Leading Role
Broadcast Film Critics Association Award for Best Actress
Blockbuster Entertainment Award for Favorite Actress – Drama
Empire Award for Best Actress
Golden Globe Award for Best Actress – Motion Picture Drama
London Film Critics Circle Film Award for Actress of the Year
Los Angeles Film Critics Association Award for Best Actress
MTV Movie Award for Best Female Performance
National Board of Review Award for Best Actress
San Diego Film Critics Society Award for Best Actress
Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role
Teen Choice Award for Film – Choice Actress
Nominated—Chicago Film Critics Association Award for Best Actress
Nominated—Las Vegas Film Critics Society Award for Best Actress
Nominated—MTV Movie Award for Best Line from a Movie (For "Bite my ass, Krispy Kreme!")
Nominated—MTV Movie Award for Most Desirable Female
Nominated—Online Film Critics Society Award for Best Actress
Nominated—Satellite Award for Best Actress - Motion Picture Drama |
| 2001 | Ocean's Eleven | Tess Ocean | Nominated—Phoenix Film Critics Society Award for Best Cast |
| 2001 | America's Sweethearts | Kathleen "Kiki" Harrison | |
| 2001 | The Mexican | Samantha Barzel | Nominated—Teen Choice Award for Film – Choice Chemistry (Shared with Brad Pitt) |
| 2002 | Confessions of a Dangerous Mind | Patricia Watson | |
| 2002 | Grand Champion | Jolene | |
| 2002 | Full Frontal | Catherine/Francesca | |
| 2003 | Mona Lisa Smile | Katherine Ann Watson | |
| 2004 | Ocean's Twelve | Tess Ocean | Nominated—Broadcast Film Critics Association Award for Best Cast |
| 2004 | Closer | Anna Cameron | National Board of Review Award for Best Cast
Nominated—Broadcast Film Critics Association Award for Best Cast |
| 2006 | Charlotte's Web | Charlotte the Spider (voice) | |
| 2006 | Beslan: Three Days In September | Narrator | |
| 2006 | The Ant Bully | Hova (voice) | Nominated—Blimp Award for Favorite Voice From an Animated Movie |
| 2007 | Charlie Wilson's War | Joanne Herring | Nominated—Golden Globe Award for Best Supporting Actress – Motion Picture |
| 2008 | Fireflies in the Garden | Lisa Waechter | |
| 2009 | Duplicity | Claire Stenwick | Nominated—Golden Globe Award for Best Actress – Motion Picture Musical or Comedy |
| 2010 | Valentine's Day | Kate | Nominated—People's Choice Award for Favorite Movie Actress (also for Eat Pray Love) |
| 2010 | Eat Pray Love | Elizabeth Gilbert | Nominated—People's Choice Award for Favorite Movie Actress (also for Valentine's Day) |
| 2011 | Larry Crowne | Mercedes Tainot | Nominated—People's Choice Award for Favorite Movie Actress |
| 2012 | Mirror, Mirror | Queen Clementianna | |
| 2012 | August: Osage County[57] | Barbara Fordham | |
| 2012 | The Normal Heart | Emma Brookner | |
